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KMID : 0376219920290020177
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Chonnam Medical Journal
1992 Volume.29 No. 2 p.177 ~ p.184
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Clinical study of traumatic tympanic membrane perforations
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Abstract
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The mammalian fetus responds to tissue injury in a fundamentally different manner than adults Normal adult wound healing results in scar formation, but fetal wounds heal without scarring.
This study was initiated to characterize fetal wounds histologically. Histologic examinationof specimens from sutured wounds on the back of fetal and adult Spargue Dawley Rats was performed by light microscopy. Microscopically, in the epidermis
of
the
fetal wound, the epithelial cell were regenerated and the cicatricial tissue was almost absent, and the dermis and the muscular layer revealed mild fibroplasia and minimal inflammatory reaction and infiltration of PAS(+) materials.
The epidermis of the adult wound recovered near normal structure by epithelial regeneration, but in contrast to those of the fetal wound, the dermis and the muscular layer frequently showed the accumulation of fibroblasts or fibroplasia, and the
remarkable increase of the capillary blood vessels, vessels, proliferation of collagen and infiltration of PAS(+) materials.
The absence of scarring and the small amounts of detectable collagen in fetal wound suggest a high degree of reorganization of the connective tissues involved in repair.
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KEYWORD
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